He was out for 85 from 115 balls as India compiled 260-9, left-arm seamer Wahab Riaz with a career-best 5-46.
Mohammad Hafeez struck 43 and Misbah-ul-Haq made a defiant 56 but Pakistan were all out for 231 in the final over.
With tickets reportedly exchanging hands for many thousands of rupees, an estimated 28,000 packed into the Punjab Cricket Association Stadium and every possible vantage point outside the ground taken, a match of such magnitude between the fierce rivals deserved to be a classic encounter.
Misbah had played a curiously subdued innings, with his first 27 taking 52 balls, and though he hit two fours and a six in six deliveries 30 were needed from the final over and India justified their decision to field three seamers by defending a relatively modest total.
The start of the India innings after they opted to bat on a pitch showing tinges of green saw Tendulkar overshadowed by the remarkable Sehwag.
With precise clips off his legs and sweetly-struck drives, Sehwag struck five fours in an over from the wayward Umar Gul and had amassed 38 by the end of the fifth over.
But he was lbw trying to turn one from Riaz to leg and as India reached 50, Tendulkar’s innings was still in its infancy with eight to his name from only 11 balls faced.